Cinalukast [Usan-Inn]
Cinalukast [Usan-Inn] - General Information
Used in the treatment of asthma, cinalukast selectively antagonizes leukotriene D4 (LTD4) at the cysteinyl leukotriene receptor, CysLT1, in the human airway. Cinalukast [Usan-Inn] inhibits the actions of LTD4 at the CysLT1 receptor, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus.
Pharmacology of Cinalukast [Usan-Inn]
Used in the treatment of asthma, cinalukast selectively antagonizes leukotriene D4 (LTD4) at the cysteinyl leukotriene receptor, CysLT1, in the human airway. Cinalukast [Usan-Inn] inhibits the actions of LTD4 at the CysLT1 receptor, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus.
Additional information about Cinalukast [Usan-Inn]
Cinalukast [Usan-Inn] Indication: For Protection against second- phase inflamation in exercise-induced bronchoconstriction and Asthma.
Mechanism Of Action: Binds to the cysteinyl leukotriene receptor. The cysteinyl leukotrienes (LTC4, LTD4, LTE4) are products of arachidonic acid metabolism and are released from various cells, including mast cells and eosinophils. These eicosanoids bind to cysteinyl leukotriene receptors (CysLT) found in the human airway. Cysteinyl leukotrienes and leukotriene receptor occupation have been correlated with the pathophysiology of asthma, including airway edema, smooth muscle contraction, and altered cellular activity associated with the inflammatory process, which contribute to the signs and symptoms of asthma.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Cinalukast
Synonyms: Not Available
Drug Category: Antiarrhythmic Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Cinalukast: Cinalukast [Usan-Inn];
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Cinalukast [Usan-Inn]: Not Available
Chemical IUPAC Name: 4-[[3-[(E)-2-(4-cyclobutyl-1,3-thiazol-2-yl)ethenyl]phenyl]amino]-2,2-diethyl-4-oxobutanoic acid
Chemical Formula: C23H28N2O3S
Cinalukast on Wikipedia: Not Available
Organisms Affected: Humans and other mammals